What is the most effective method to eliminate a 60Hz artifact?

The most effective method to eliminate a 60Hz artifact is through common mode rejection. This technique is used in differential amplifiers to filter out noise that affects both input signals equally, which is prevalent in many physiological signals being measured, such as EEG, EOG, or EMG.

In the context of a 60Hz artifact, which is often caused by electrical interference from power lines or other electrical equipment, common mode rejection helps to minimize the effect of this noise by effectively canceling it out. The differential amplifier processes the signals from the measurement electrodes and enhances the desired biological signal while suppressing the common noise, thereby improving the quality of the data collected.

While grounded equipment can help reduce electrical interference and employing low impedances can improve signal quality, these measures do not specifically target the 60Hz artifact as effectively as common mode rejection does. Avoiding extension cords is a preventive measure but does not provide a method to actively filter out the 60Hz interference once it is present in the signal.